منابع مشابه
Chaperone - Mediated Autophagy Regulation of Neuronal Survival
www.sciencemag.org (this information is current as of January 22, 2009 ): The following resources related to this article are available online at http://www.sciencemag.org/cgi/content/full/323/5910/124 version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/cgi/content/full/323/5910/124/DC1 can be foun...
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All intracellular proteins undergo continuous synthesis and degradation. Chaperone-mediated autophagy (CMA) is necessary to maintain cellular homeostasis through turnover of cytosolic proteins (substrate proteins). This degradation involves a series of substrate proteins including both cancer promoters and suppressors. Since activating or inhibiting CMA pathway to treat cancer is still debated,...
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Intracellular protein degradation rates decrease with age in many tissues and organs. In cultured cells, chaperone-mediated autophagy, which is responsible for the selective degradation of cytosolic proteins in lysosomes, decreases with age. In this work we use lysosomes isolated from rat liver to analyze age-related changes in the levels and activities of the main components of chaperone-media...
متن کاملChaperone-mediated autophagy at a glance.
autophagy at a glance Susmita Kaushik1, Urmi Bandyopadhyay1,*, Sunandini Sridhar1, Roberta Kiffin1, Marta Martinez-Vicente1,‡, Maria Kon1, Samantha J. Orenstein1, Esther Wong1 and Ana Maria Cuervo1,§ 1Department of Developmental and Molecular Biology and Institute for Aging Studies, Albert Einstein College of Medicine, Bronx, NY 10461, USA *Present address: Department of Genetics, Yale Universi...
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AIMS Chaperone-mediated autophagy (CMA) is a selective mechanism for the degradation of soluble cytosolic proteins bearing the sequence KFERQ. These proteins are targeted by chaperones and delivered to lysosomes where they are translocated into the lysosomal lumen and degraded via the lysosome-associated membrane protein type 2A (LAMP-2A). Mutations in LAMP2 that inhibit autophagy result in Dan...
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ژورنال
عنوان ژورنال: Autophagy
سال: 2007
ISSN: 1554-8627,1554-8635
DOI: 10.4161/auto.4144